Ifsamide-M Injection a formulation of ifosfamide combined with mesna, a protective agent that mitigates the urotoxic effects of ifosfamide. Ifosfamide is an alkylating agent commonly used in chemotherapy regimens to treat various cancers, including lymphomas, sarcomas, and testicular cancer. Mesna, on the other hand, serves as a uroprotective agent by neutralizing acrolein, the key toxic metabolite responsible for causing hemorrhagic cystitis.
Mesna binds with acrolein to form a non-toxic compound that is excreted in the urine, thus reducing the risk of bladder damage.